Insulin resistance and cancer

In the 8th Annual World Congress on Insulin Resistence, Diabetes and Cardiovascular which took place in Los Angeles, discussed the relation of insulin resistance and cancer. Herdie in his studies of researchers a motivator for AMPK and cancer describes breast cancer and colorectal cancer is especially associated with obesity and insulin resistance. AMPK activation leads to cell cycle of cancer cells at a standstill while the AMPK role to stop the activity of rapamycin (mTOR) which is activated within the tumors.

On breast cancer, the activation of AMPK is reduced which may be a mechanism for the development of cancer so in awarding research provides a benefit that patient metformin diabetes who get cancer incidents and metformin decreases metformin slowed the development of cancer in some animal models. Metformin will activate AMPK hepatic, lowering blood glucose levels, insulin and IGF1 so obtained anticancer effect.

Researcher Lorraine Lipscombe (Toronto, Canada) is also reviewing the existence of a link between cancer and diabetes and insulin resistance, some large clinics test data to see the relationship between cancer and type 2 diabetes, the initial report is from pancreatic cancer increased in patients who have been exposed to the old hepatoselular cancer diabetes, also associated with diabetes in patients without hepatitis C was found with the risk and non-alcoholic steatohepatitis cirrosis. Endometrial cancer has long been known as related to obesity is similar to the increased production of estrogens from adipose, but the influence of diabetes without obesity related also obtained on colorectal cancer.

In a review of clinical trials on patients with diabetic woman 75,000 control group showed cases of breast cancer is 2,85 vs. 2.64 per 1000/year, there was an increase of 8% to control obesity and other risk factors. Thus diabetes or any matters related to the diabetes appears to contribute to increased risk of breast cancer. In a meta-analysis of diabetes is also found in association with diabetes, the pancreas carcinoma liver and kidney, endometrium and although not as strong as the above, as well as cancer diabetes associated with colorectal cancer, and bladder cancer and little also looks at the rise in cases of cancer lymphoma.

The manarik is the Genesis cancer prostate decreased in patients of diabetes, researcher’s suspect possible relation between Lipscombe high occurrences of hipogonadisme. Potential mechanisms of diabetes trigger, the ferocity of the existence of the relationship between Hyperglycemia or the existence of indirect relationship between insulin resistance, inflammation, lipids and fatty acids that are abnormal, adipokine or IGF-1.

Another researcher, Warburg gave the dominant hypothesis of cancer cells use Glycolysis to gain energy and require high glucose conditions so that hyperglycemia gives a good environment for the development of cancer. Data intensive glucose control in relation to cancer and mortality of patients with cancer is still unclear, but the data showed a higher kegenasan happens by 30% in patients who get in the sulfonylurea and 90% compared to the patients of diabetes with insulin group who get metformin.

Researcher Pamela Goodwin (Toronto, Canada) further discusses the relationship between violence and the influence of insulin, metformin. A high BMI levels have a high risk of rekurensi cancer and increased mortality at local breast cancer with mediator poten i.e. inflammatory, adipokine, insulin, IGF and estrogen that may be related to one another. Cancer seen experiencing high expression of insulin levels, IGF-1, and hybrid receptors related to bad therapy results.

The alpha Isoform terekspresi on breast cancer is fatal receptors that would bind with IGF1 and IGF2 and menswitch will help metabolic process of insulin became influential lawsuit against mitogenik and anabolic steroid.

Advantages of the use of metformin is quite effective against several different subtypes of breast cancer but the difference that looks most effective is the triple negative breast cancer by pressing therapy resistance in human epidermal growth factor-2, increasing the effects of aromatase inhibitors and metformin in the animals try to look down the karsionogenesis lung induced by tobacco and provide benefit in the prevention of colon cancer.